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© 1994 British Society for Rheumatology

research-article

SYSTEMIC LUPUS ERYTHEMATOSUS AND ACUTE DEMYELINATING POLYNEUROPATHY

M. G. ROBSON, M. J. WALPORT and K. A. DAVIES*

Rheumatology Unit, Royal Postgraduate Medical School, Hammersmith Hospital Du Cane Road, London W12 0NN

Correspondence to: *Author to whom correspondence should be addressed.

Guillain-Barré syndrome has been described only rarely in patients with SLE. In this Grand Round we describe a 33-yr-old patient who presented with features of central nervous system lupus, thrombocytopenia, and a severe haemolytic anaemia. Within a few days of her admission, following the commencement of steroid therapy, and a grand mal seizure, the patient developed paralysis of her lower limbs, due to an acute demyelinating polyneuropathy, and subsequently a retinal vasculitis. We discuss the epidemiological and possible immunopathological links between SLE and Guillain-Barré syndrome, and possible treatment strategies.

KEY WORDS: Systemic lupus erythematosus, Guillain-Barré syndrome, Polyneuropathy, Retinal vasculitis


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