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© 1994 British Society for Rheumatology

research-article

HLA-DRB GENES AND ANTIRIBOSOMAL P ANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS

L. S. TEH*,, D. G. DOHERTY{dagger} and B. D. WILLIAMS*

*Rheumatology Research Centre, University Hospital of Wales Heath Park, Cardiff CF4 4XW
{dagger}Institute of Liver Studies, King's College Hospital and School of Medicine and Dentistry Denmark Hill, London SE5 9RS

Correspondence to: Correspondence to: L. S. Teh, Rheumatic Diseases Centre, University of Manchester, Hope Hospital, Salford M6 8HD.

Antibodies to the ribosomal P protein are specific for SLE but their prevalence varies in different ethnic groups. In a group of Chinese SLE patients from Malaysia who have a high prevalence of this antibody, we have found an increased frequency of an uncharacterized HLA-DRB gene allele, DR16X, in patients who are positive for anti-P antibodies compared to antibody negative patients (31.3% vs 3.2%, P<0.01, Pcorr not significant, relative risk = 13.6). DR16X has only been found in south east Asian populations and may be a genetic factor which influences the high prevalence of anti-P antibodies in Chinese.

KEY WORDS: Antiribosomal P protein antibodies, HLA-DRB alleles, Systemic lupus erythematosus, Malaysian Chinese


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