© 1994 British Society for Rheumatology
research-article |
REACTIVE ARTHRITIS FOLLOWING AN OUTBREAK OF SALMONELLA INFECTION IN FINLAND
*Laboratory of Enteric Pathogens, National Public Health Institute Helsinki
Second Department of Medicine, Helsinki University Central Hospital Helsinki
Finnish Red Cross Blood Transfusion Service Helsinki
National Public Health Institute, Department in Turku Finland
Correspondence to:
Correspondence to: A. Siitonen, National Public Health Institute, Mannerheimintie 166, FIN-00300 Helsinki, Finland.
The incidence and clinical features of reactive arthritis (ReA) following an outbreak of enteritis caused by Salmonella enterica ssp. enterica serovar 4,5,12: b:- were studied in the autumn of 1992. The outbreak occurred in several municipalities and originated from sprouted mung beans.
A questionnaire on extra-enteric manifestations such as joint and eye symptoms was mailed 2 to 5 months after the outbreak to all bacteriologically proven cases. Two hundred and forty-six of the 272 (90%) subjects responded to the questionnaire; 224 (91%) reported having had enterocolitis, 22 (9%) were asymptomatic.
Sixteen subjects fulfilled the criteria for ReA, and one had irities only. Thus, the incidence of ReA/iritis after S enterica was 6.9%. Only four of the 155 (3%) subjects aged less than 16 yr developed ReA, as compared with 12 of the 91 (137%) older patients (P<0.001). The only patient with iritis was also more than 16 yr old. The joint symptoms were oligoarticular in 10 (63%), monoarticular in five (31%) and polyarticular in one (6%). The most frequently affected joints were the wrists, knees and ankles. Joints of upper extremities only were affected in three (19%), of the lower extremities only in six (37%) and of both in seven (44%) subjects. In the majority of the patients ReA was mild. The joint symptoms persisted for less than 1 month in six, 2 to 6 months in five and more than 6 months in five. Thirteen subjects with ReA/iritis were tissue typed for HLA; four (33%) had HLA-B27. Three HLA-B27-negative subjects had antigens of HLA-B27 crossreacting groups; two had B40 and one B7. The duration or severity of arthritis were similar in the HLA-B27 positive and negative patients.
KEY WORDS: Reactive arthritis, Salmonella infection, Mung bean sprouts, Extra-enteric manifestation
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T Hannu, L Mattila, A Siitonen, and M Leirisalo-Repo Reactive arthritis attributable to Shigella infection: a clinical and epidemiological nationwide study Ann Rheum Dis, April 1, 2005; 64(4): 594 - 598. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Hannu, L Mattila, J P Nuorti, P Ruutu, J Mikkola, A Siitonen, and M Leirisalo-Repo Reactive arthritis after an outbreak of Yersinia pseudotuberculosis serotype O:3 infection Ann Rheum Dis, September 1, 2003; 62(9): 866 - 869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T Hannu, L Mattila, A Siitonen, and M Leirisalo-Repo Reactive arthritis following an outbreak of Salmonella typhimurium phage type 193 infection Ann Rheum Dis, March 1, 2002; 61(3): 264 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hannu, L. Mattila, H. Rautelin, P. Pelkonen, P. Lahdenne, A. Siitonen, and M. Leirisalo-Repo Campylobacter-triggered reactive arthritis: a population-based study Rheumatology, March 1, 2002; 41(3): 312 - 318. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Rudwaleit, S Richter, J Braun, and J Sieper Low incidence of reactive arthritis in children following a salmonella outbreak Ann Rheum Dis, November 1, 2001; 60(11): 1055 - 1057. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F T Kerkhoff and A Rothova Bartonella henselae associated uveitis and HLA-B27 Br. J. Ophthalmol., October 1, 2000; 84(10): 1125 - 1129. [Abstract] [Full Text]
|
|
|
|
|
|
P. Toivanen and A. Toivanen Two forms of reactive arthritis? Ann Rheum Dis, December 1, 1999; 58(12): 737 - 741. [Abstract] [Full Text]
|
|
|
|
|
|
H.-I. Huppertz and J. Heesemann Invasion and persistence of Salmonella in human fibroblasts positive or negative for endogenous HLA B27 Ann Rheum Dis, November 1, 1997; 56(11): 671 - 676. [Abstract] [Full Text]
|
|
|
|
|
|
M Leirisalo-Repo, P Helenius, T Hannu, A Lehtinen, J Kreula, M Taavitsainen, and S Koskimies Long term prognosis of reactive salmonella arthritis Ann Rheum Dis, September 1, 1997; 56(9): 516 - 520. [Abstract] [Full Text]
|
|