© 1994 British Society for Rheumatology
research-article |
AUTOANTIBODIES TO MYELOPEROXIDASE IN IDIOPATHIC AND DRUG-INDUCED SYSTEMIC LUPUS ERYTHEMATOSUS AND VASCULITIS
*Department of Immunology, Faculty of Clinical Sciences, University College London
Department of Rheumatology, Manchester Royal Infirmary Manchester
Department of Nephrology, Institute of Nephrology and Urology, University College London
Correspondence to:
G. Cambridge, Department of Immunology, Arthur Stanley House, Middlesex Hospital, London W1P 9PG.
Circulating antibodies to myeloperoxidase (MPO) have been described in a variety of vasculitic syndromes, drug-induced SLE and drug-induced nephritis. We have examined the autoantibody profile in acute sera from patients with anti-neutrophil cytoplasmic antibody-positive vasculitis (n = 8), drug-induced nephritis (n = 4), drug-induced lupus (n = 7), SLE (n = 27) and nephritis-associated with SLE (n = 17). Significant binding to purified MPO in ELISA was given by all sera from patients with vasculitis and drug-induced nephritis but ANA sought by indirect immunofluorescence on HEp-2 cells were not detected. Both anti-MPO and ANA were found in sera from patients with drug-induced lupus. Sera from patients with SLE or SLE nephritis did not contain high titres of anti-MPO antibodies but invariably contained ANA. Anti-MPO antibodies of both IgG and IgM classes were present in all sera from patients with drug-induced disease. Although the number of samples tested was small, sera from patients with drug-induced nephritis showed significantly greater median % binding of IgM to MPO compared with drug-induced SLE. Binding to MPO by IgG in these sera was not significantly different. These findings suggest that the mechanism of interaction between hydralazine and the immune system in the two drug-induced autoimmune diseases studied may contribute to their distinct clinical features.
KEY WORDS: Anti-neutrophil cytoplasmic autoantibodies, Myeloperoxidase, Autoantibodies, Systemic lupus erythematosus, Vasculitis
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