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© 1994 British Society for Rheumatology

research-article

REDUCED ACTIVITY OF SERUM CREATINE KINASE IN RHEUMATOID ARTHRITIS: A PHENOMENON LINKED TO THE INFLAMMATORY RESPONSE

R. SANMARTÍ*, A. COLLADO*, J. GRATACÓS{dagger}, J. L. BEDINI{ddagger}, D. PAÑELLA{dagger}, X. FILELLA{ddagger}, J. LLENA* and J. MUÑOZ-GOMEZ*

*Rheumatology Service, Hospital Clinic de Barcelona Barcelona
{dagger}Department of Internal Medicine (Rheumatology Unit),Hospital General de Vic Vic, Barcelona
{ddagger}Department of Biochemistry, Hosipital Clinic de Barcelona Barcelona, Spain

Correspondence to: R. Sanmarti, Rheumatology Serivice, Hospital Clinic i Provincial, Villarroel 170, 08036 Barcelona, Spain

In a case-controlled study, serum creatine kinase (CK) activity was sigrulicantly lower in 40 patients with RA than in 40 age- and sex-matched patients with non-inflammatory arthropathies [mean 37.6 (s.D. 29.2) vs 77.7 (s.D. 45.3) IU/I respectively P<0.0001]. In contrast, serum levels of aldolase and myosin were not significantly ower in RA patients. A significant inverse correlation between CK activity and ESR, CRP and platelet count was observed in RA. There was also a positive correlation between haemoglobin levels and CK values No correlation was found between CK activity and a meager mass index, disease duration and radiological erosion. No inhibitor of CK activity in the sera of RA patients was found. CK serum activity was markedly reduced in RA, and is related to the inflammatory activity of the disease. This finding may stimulate further exploration on the effect of inflammatory response in muscle metabolism.

KEY WORDS: Serum creatine kinase, Rheumatoid arthritis, Mammatory response, Disease activity, Rheumatoid myositis


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