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© 1994 British Society for Rheumatology

research-article

BIOAVAILABILITY OF HYDROXYCHLOROQUINE TABLETS IN PATIENTS WITH RHEUMATOID ARTHRITIS

A.J. McLACHLAN*,{dagger}, S. E. TETT{ddagger}, D. J. CUTLER* and R. O. DAY{ddagger},§

*Departments of Pharmacy, University of Sydney NSW 2006, Australia
{ddagger}Departments of Clinical Pharmacology, St Vincent's Hospital Darlinghurst, NSW 2010, Aurtralia
§Department of Rheumatology, St Vincent's Hospital Darlinghurst, NSW 2010, Aurtralia

Correspondence to: Correspondence to S. Tett

Nine patients with RA received two doses of 155 mg racemic hydroxychloroquine each, as a tablet and by i.v. infusion, in a randomized cross-over design study. Blood concentrations over the first 32 h following each dose were determined. Bioavailability was estimated using a sequential exponential least squares deconvolution method.

The mean fraction absorbed from the tablet was 0.79 (range 0.39 to 1.27). The mean absorption lag-time was 1.3 h (range 0.5 to 3.7 h) and the mean time for 50% absorption was 4.3 h (range 1.9 to 10.3 h). Mean rate and extent of hydroxychloroquine absorption were not significantly different from that previously reported for healthy volunteers, although the interindividual variability in absorption parameters was greater in the patient group. Variability in the extent of absorption would lead to differences in steady-state hydroxychloroquine concentrations between patients, potentially contributing to the variability in response observed in clinical practice.

KEY WORDS: Pharmacokinetics, Hydroxychloroquine, Bioavailability

{dagger}Present address: Department of Pharmacy, University of Manchester, Manchester M13 9L


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