Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BLANCO, F. J.
Right arrow Articles by GÓMEZ-REINO, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by BLANCO, F. J.
Right arrow Articles by GÓMEZ-REINO, J. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1994 British Society for Rheumatology

research-article

LIGHT, IMMUNOFLUORESCENCE AND ELECTRON MICROSCOPY RENAL BIOPSY FINDINGS AS PREDICTORS OF MORTALITY IN EIGHTY-FIVE SPANISH PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

F. J. BLANCO*, J. DE LA MATA*, J. I. LÓPEZ-FERNÁNDEZ{dagger} and J. J. GÓMEZ-REINO{dagger}

*Rheumatology Hospital Doce de Octubre Madrid, Spain
{dagger}Pathology Units, Hospital Doce de Octubre Madrid, Spain

Correspondence to: J. J. Gémez-Reino, Rheumatology Unit, Hospital Doce de Octobre, Ca de Andalucia, 28041 Madrid, Spain

This study aimed to define prognostic indicators of death in renal biopsies from Spanish patients with SLE. Renal biopsies of eighty-five lupus patients with and without clinical nephritis, taken betweeen 1974 and 1987, were reviewed. Samples previously processed for light (LM), immunofluorescence (IM) and electron (EM) microscopy were analysed blind. Kaplan-Maier curves, log-rank test, and multivariate Cox's regression statistical methods were used for comparison of biopsy data in relation to patient survival. Univariate analysis showed that vascular hyalinosis, glomerular sclerosis, fibrous crescent and chronicity index higher than 3 by LM, and intramembranous dense-deposits by EM are predictors of poor survival. A multivariate approach confirmed the independent influence of vascular hyalinosis, chronicity index higher than 3 and intramembranous deposits. A predictive model can be constructed with three LM (hyalinosis, tubular atrophy and glomerular sclerosis) and three EM variables (subepithelial, mesangial and intramembranous deposits). Selected renal biopsy changes detected by LM and EM are therefore predictors of death in patients with lupus. Chronicity markers, more than those of activity or severity, are the best prognostic indicators.

KEY WORDS: Lupus nephritis, Predictors of mortality in SLE, Survival in lupus nephritis, Electron microscopy, Light microscopy


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 LupusHome page
W J McCune, M Saluja, S Bhat, L A Lange, L Holzman, and K Johnson
Correlation of membranous glomerular ultrastructural changes with disease severity and outcome in lupus patients initiating cyclophosphamide therapy
Lupus, June 1, 2005; 14(6): 426 - 433.
[Abstract] [PDF]

Home page
 LupusHome page
F J Blanco, J J Gomez-Reino, J de la Mata, A Corrales, V Rodriguez-Valverde, J C Rosas, A G. de la Camara, and E Pascual
Survival analysis of 306 European Spanish patients with systemic lupus erythematosus
Lupus, March 1, 1998; 7(3): 159 - 163.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.