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© 1994 British Society for Rheumatology

case-report

POLYARTHRITIS ASSOCIATED WITH HEPATITIS C VIRUS INFECTION

Y. UENO*, R. KINOSHITA{dagger}, I. KISHIMOTO{ddagger} and S. OKAMOTO{ddagger}

*Department of Medicine, Shichikawa Arthritis Reaearch Center Mie
{dagger}Departments of Gastroenterology Takatsuki Red Cross Hospital Osaka, Japan
{ddagger}Orthopaedic Surgery, Takatsuki Red Cross Hospital Osaka, Japan

Correspondence to: Y. Ueno, Shichikawa Arthritis Research Center, 5630 Sakakibara, Hisai, Mie, 514-12 Japan

Two cases of polyarthritis associated with hepatitis C infection are reported. In Patient 1, stiffness and polyarthritis occurred during the acute stage of hepatitis. The arthritic symptoms lasted for 4 months. A transient polyarthritis recurred 4 yr later. The persistent presence of anti-hepatitis C viral antibodies was noted. Hepatitis C viral RNA (HCV RNA) was identified in the serum using the polymerase chain reaction proving that the patient was a carrier. In Patient 2, polyarthritis occurred associated with chronic hepatitis C liver disease. Synovial iopsy showed infiltration of mononuclear cells HCV RNA was demonstrated in both serum and SF. These cases suggest an aetiologic association between arthritis and hepatitis C antigenaemia.

KEY WORDS: Polyarthritis, Hepatitis C virus carrier, Chronic antigenaemia


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