© 1994 British Society for Rheumatology
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DETECTION OF CYTOMEGALOVIRUS, EPSTEIN–BARR VIRUS AND HERPES VIRUS-6 IN PATIENTS WITH RHEUMATOID ARTHRITIS WITH OR WITHOUT SJÖGREN'S SYNDROME
The Department of Medicine, Division of Rheumatology, Montreal General Hospital, McGill University Canada
Correspondence to:
Correspondence to: M. M. Newkirk, Montreal General Hospital Research Institute, 1650 Cedar Avenue, Montreal, Quebec H3G 1A4, Canada.
The frequency of latent viral infection by cytomegalovirus (CMV), Epstein–Barr virus (EBV) and herpes virus-6 (HHV-6) was investigated in patients with RA with or without Sjögren's syndrome (SS) and in normal controls. Virus presence was determined by polymerase chain amplification of DNA isolated from peripheral blood mononuclear or polymorphonuclear cells and/or saliva-derived mononuclear/epithelial cells. Anti-viral antibodies and autoantibodies were also assayed. Patients with RA both with and without SS were found to have a significantly increased frequency of latent viral infection (two-fold higher, P = 0.035 for EBV and seven-fold higher, P = 0.018 for HHV-6) compared to normal controls but only in cells isolated from saliva. The increased frequency of virally infected cells from the saliva of patients with RA, regardless of the SS status, when compared to normal controls may reflect the ongoing inflammatory process, the impact of therapy and/or a less effective local immune responsiveness.
KEY WORDS: Rheumatoid arthritis, Sjögren's syndrome, Cytomegalovirus, Epstein-Barr virus, Herpes virus-6
*Current address: Rheumatology, Cleveland Clinic Florida, Fort Lauderdale, FL, USA.
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