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© 1994 British Society for Rheumatology

case-report

APLASTIC ANAEMIA ASSOCIATED WITH FENBUFEN: A REPORT OF TWO CASES

K. W. MUIR*, T. HOLYOAKE{dagger} and E. FITZSIMONS{ddagger},

*Department of Medicine and Therapeutics, Western Infirmary Glasgow G11 6NT
{dagger}CRC Beatson Laboratories, Garscube Estate Switchback Road, Bearsden, Glasgow G61 1BD
{ddagger}Monklands District General Hospital Monkscourt Avenue, Airdrie ML6 0JS

Correspondence to: Correspondence to E. Fitzsimons.

We report two cases of aplastic anaemia occurring in patients after exposure to the NSAID fenbufen. In each case, the patient had not been exposed to other drugs in this class, and was on no concomitant medication which has previously been associated with this complication. Failure of in vitro growth of haemopoietic progenitor cells in clonogenic assays confirmed the diagnosis of aplasia, and also confirmed that aplasia induced by this agent is not due to the presence of any humoral inhibitory factor, but to an intrinsic abnormality in the pluripotent stem cells. Aplastic anaemia is a recognized, but extremely rare, complication of exposure to NSAIDs of any chemical subtype.

KEY WORDS: Aplastic anaemia, Fenbufen, Non-steroidal anti-inflammatory drugs, Adverse drug reactions, Haemopoiesis, Colony-forming units, Immunosuppression


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