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© 1994 British Society for Rheumatology

case-report

ACUTE INFLAMMATORY POLYARTHRITIS IN ASSOCIATION WITH TAMOXIFEN

P. CREAMER, K. LIM, E. GEORGE and P. DIEPPE

Rheumatology Unit, Bristol Royal Infirmary Bristol BS2 8HW

The antioestrogen drug tamoxifen is widely used to treat breast carcinoma. We report three cases in which its use was temporally related to the development of an acute inflammatory polyarthritis resembling RA; a side-effect not previously reported. Possible mechanisms for such an effect are discussed.

KEY WORDS: Tamoxifen, Oestrogen, Breast carcinoma, Polyarthritis


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