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© 1994 British Society for Rheumatology

research-article

HLA CLASS 2 GENES IN SINGAPOREAN CHINESE RHEUMATOID ARTHRITIS

S. H. CHAN*,{dagger},, Y. N. LIN{dagger}, G. B. WEE*, W. H. KOH{ddagger} and M. L. BOEY{ddagger}

*Department of Microbiology, Faculty of Medicine, National University of Singapore Moulmein Road, Singapore
{dagger}WHO Immunology Centre, Faculty of Medicine, National University of Singapore Moulmein Road, Singapore
{ddagger}Medical Unit IV, Tan Tock Seng Hospital Moulmein Road, Singapore

Correspondence to: S. H. Chan, WHO Immunology Centre, Faculty of Medicine, National University of Singapore, Singapore 0511.

This study analysed HLA class 1 and 2 allele associations in Singaporean Chinese patients with RA. Seventy patients (ARA definite or classical) and 80 controls were typed for HLA class 1 alleles by serology and class 2 alleles by serology and the PCR/SSO method. RA patients had higher frequencies of DRB1*0405 (40 vs 12.5%; corrected probability value (PC)<0.02, relative risk (RR) = 4.7, 95% confidence limit (CL) 2.1–10.6), DRBl*1001 (14.3 vs 1.3%; PC = 0.06, RR = 13.2,95% CL 1.6–105.7), DQB1*0401 (38.6 vs 125%; P = 0.006, RR = 4.4,95% CL 1.9–10.0) and DQB1*0501 (20 vs 5%; PC = 0.048, RR = 4.8, 95% CL 1.5–15.2). It is concluded that Chinese RA is associated primarily with HLA DRB1*0405 and DRBl*1001 which share common amino acid sequences in the third hypervariable region of the DRß chains shown to be associated with RA in other ethnic groups. Patients without DRB1*0405 and *1001 had a higher frequency of DRB1*0901, which is in linkage disequilibrium with HLA B46 in the Chinese.

KEY WORDS: HLA Class II, Chinese rheumatoid arthritis


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