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© 1995 British Society for Rheumatology

research-article

DETECTION OF ANTIRIBOSOMAL P PROTEIN ANTIBODIES IN PATIENTS WITH SYSTEMIC SCLEROSIS

M. FUJIMOTO*, S. SATO*, K. TAKEHARA*, Y. NOJIMA{dagger}, Y. SOMA{ddagger}, K. KIKUCHI*, H. IHN*, A. IGARASHI* and K. TAMAKI*

*Department of Dermatology Tokyo, Japan
{dagger}Third Department of Internal Medicine, Faculty of Medicine, University of Tokyo Tokyo
{ddagger}Division of Dermatology of Tokyo Metropolitan Police Hospital Tokyo, Japan

This study investigated the prevalence and clinical significance of anti-ribosomal P protein (anti-P) antibodies in patients with systemic sclerosis (SSc). Serum samples from 150 patients with SSc were examined by indirect immunofluorescence, ELISA and immunoblotting. Anti-P antibodies were detected in four (3%) patients with SSc. Three of the four patients showed SSc/SLE (systemic lupus erythematosus) overlap syndrome, but psychiatric disorders were not observed in these patients. By longitudinal immunoblotting analysis one patient, who was initially diagnosed with SSc, later developed anti-P antibodies along with clinical manifestations of SLE. Our data suggest that anti-P antibodies are uncommon in SSc and that the presence of anti-P antibodies in patients with SSc indicates an overlap with SLE.

KEY WORDS: Anti-ribosomal P protein antibodies, Systemic sclerosis, Systemic lupus erythematosus


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