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© 1995 British Society for Rheumatology

research-article

DIFFERENT ABDOMINAL SCINTIGRAPHY PATTERN IN PATIENTS WITH ULCERATIVE COLITIS, CROHN'S DISEASE AND SERONEGATIVE SPONDYLARTHROPATHIES*

J.C. ALONSO{dagger}, F.J. LÖPEZ-LONGO, J.L. LAMPREAVE{dagger}, M. GONZÁLEZ, L. ALMOGUERA{dagger} and L. CARREÑO{dagger},

Department of Rheumatology, ’Hospital Universitario Gregorio Marañón‘ Universidad Complutense Madrid, spain
{dagger}Department of Nuclear Medicine, ’Hospital Universitario Gregorio Marañón‘ Universidad Complutense Madrid, spain

Correspondence to: Correspondence to: L. Carreño, Servicio de Reumatología, Hospital Gregorio Marañón, C/ Doctor Esquerdo 46, 28007–Madrid,Spain.

The aim was to analyse the abdominal scintigraphy pattern in patients with seronegative spcondylarthropathy (Ssp), ulcerative colitis (UC) and Crohn's disease (CD). A total d 117 patients with defined histological lesions of inflammatory bowel disease(IBD) (68 UC and 49 CD), 32 patients with active SSp [European Spondylarthropathy Study Group (ESSG) 1991 criteria] without clinical evidence of IBD and 21 controls witbout 18D or SSp were studied. All patients with SSp and controls received similar doses of non-steroidal anti-inflammatory drugs. Abdominal scintigraphy images were obtained at 30 and 120 min after injection of 99m-technetium hexamethyl propylene amine oxime 99mTc-HMPAO)-labelled leucocytes.The 99mTc-HMPAO-labelied leucocyte scan was positive in 17 patients with Ssp (53.1%), 45 patients with WC (66.1%) and 33 patients with CD (67.3%). Rectum and sigma involvement was more frequent in patients with UC (68.8%) than in patients with SSp (23.5%)or CD (33.3%) (P<0-05) [odds ratios (OR): 7.1 and4.4, respectively]. Terminal ileum involvement was more frequent in patients with CD (63.6%) than in patients with SSp (23.5%) or UC (8.8%) (P <0.05) (OR: 5.6 and 17.9, respectively). The99cmTc- HMPAO-labled leucocyte scan shows an increased uptake in patients with SSp without evidence or IBD. Perhaps these patients represent one end of the spectrum of IBD, but rectal and terminal ileum involvement were less fizquent in patients with SSp than in patients with UC or CD.

KEY WORDS: Inflammatory bowel diesease, 99cmTc-HMPAO-labelled leucocyte scintigraphy, Seronegative Spondylarthropathies

*Preliminary results presented at the 58th Annual scientific Meeting of the American College of Rheumatology, Minneapolis, Minnesota, October 23–27, 1994


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