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© 1995 British Society for Rheumatology

case-report

DESTRUCTIVE LYMPHADENOPATHY AND T-LYMPHOCYTE ACTIVATION IN ADULT-ONSET STILL’S DISEASE

M. KOELLER*,, H. KIENER*, I. SIMONITSCH{dagger}, M. ARINGER*, C. W. STEINER*, K. MACHOLD* and W. GRANINGER*

*Department of Internal Medicine III, Division of Clinical Rheumatology
{dagger}Institute of Clinical Pathology, University of Vienna Austria

Correspondence to: Correspondence to: M. Koeller, University of Vienna, Department of Internal Medicine III, Division of Clinical Rheumatology, Neues AKH, Währinger Gürtel 18–20, A-1090 Vienna, Austria.

Recurrent arthritis, fever and lymphadenopathy are symptoms of adult onset of Still's disease (AOSD). Differential diagnosis requires the exclusion of infections or malignant lymphomas. We report on a case of AOSD showing destructive lymphadenopathy, immunophenotyping of peripheral blood leucocytes revealed strong activation of T-lymphocytes. Bone marrow biopsy also showed an increase of lymphopoietic cells to 23%. Analysis of peripheral blood lymphocytes (PBL) after remission showed no remaining signs of activation. Analysis of lymphocyte activation by flow cytometry correlated with disease activity.

KEY WORDS: Still's disease, Lymphadenopathy, Lymphocyte activation, Flow cytometry


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