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© 1995 British Society for Rheumatology

research-article

ABSENCE OF CORRELATION BETWEEN IL-l{alpha} INTRON 6 POLYMORPHISM AND RHEUMATOID ARTHRITIS

S. BAILLY, G. HAYEM*, M. FAY, M. F. KAHN* and M. A. GOUGEROT-POCIDALO

INSERM U294, CHU X. Bichat Pairs, France
*Service of Rheumatology, CHU Bichat Paris, France

Correspondence to: Correspondence to: S. Bailly, INSERM U294, Faculté de Médecine X. Bichat, bp 416, 75870 Paris, France.

Several studies have implicated interleukin l{alpha} (IL-l{alpha}) in the pathogenesis of rheumatoid arthritis (RA). We analysed IL-l{alpha} intron 6 polymorphism in relation to RA (50 patients with RA and 50 healthy controls). The study of a healthy control population confirmed the existence of the different alleles with a frequency similar to that in the Caucasian population of northern England. Allele and genotype distributions did not differ significantly between the normal and RA populations, although the allele corresponding to 8 repeats was over-represented in the RA population (8 and 14% in the healthy and RA populations, respectively). This suggests that IL-l{alpha} intron 6 polymorphism could be part of a complex process involving other unidentified genetic factors in the pathogenesis of RA.

KEY WORDS: Interleukin l{alpha}, Rheumatoid arthritis, Genetic polymorphism, Intron 6


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