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© 1995 British Society for Rheumatology

research-article

FOLATE SUPPLEMENTATION AND METHOTREXATE

B. A. C. DIJKMANS

Department of Rheumatology, University Hospital Leiden Building I, C4-R, PO Box 9600, 2300 RC, Leiden, The Netherlands

This review concentrates on the influence of folate supplementation on the toxicity and efficacy of methotrexate (MTX) in rheumatoid arthritis patients. The design, type of folate supplementation and timing of supplementation vary considerably between the six published controlled studies. Folate supplementation seems to have no effect on the efficacy of MTX but may influence toxicity in a favourable way. Further studies are needed to assess the type of supplementation (folic acid, folinic acid), the predisposing factors for toxicity and cost effectiveness.

KEY WORDS: Folate, Folic acid, Folinic acid, Methotrexate


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