Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by VANDEVYVER, C.
Right arrow Articles by RAUS, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by VANDEVYVER, C.
Right arrow Articles by RAUS, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 British Society for Rheumatology

research-article

PEPTIDE TRANSPORTER GENES (TAP) POLYMORPHISMS AND GENETIC SUSCEPTIBILITY TO RHEUMATOID ARTHRITIS

C. VANDEVYVER, P. GEUSENS, J.-J. CASSIMAN and J. RAUS

Dr L. Willems-Instituut, Limburgs Universitair Centrum Diepenbeek
Department of Rheumatology Leuven, Belgium
Centrum voor Menselijke Erfelijkheid, Katholieke Universiteit Leuven Leuven, Belgium

The association of rheumatoid arthritis (RA) with HLA-DRB1 allelcs indicates that at least one RA susceptibility gene is linked to the HLA class II region. Transporter associated with protein processing (TAP) genes, which lie upstream of the HLA-structural genes, may also contribute to disease susceptibility. We investigated polymorphisms of the peptide transporter genes, TAP 1 and TAP 2, by PCR-ASO hybridization techniques in 82 RA patients and 66 control individuals. Although there was a suggestion of linkage between some TAP polymorphisms and RA, these seem to be dependent on HLA-DRB1*04, since these positive associations disappeared when HLA-DRB1*04 positive RA patients and controls were compared. Furthermore, no particular TAP allele or haplotype was associated with any clinical or immunological subgroup of RA. We conclude that the TAP genes do not have a major influence on susceptibility to RA in the European Caucasian population.

KEY WORDS: Rheumatoid arthritis, Susceptibility, Transporter genes


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Ann Rheum DisHome page
F Castro, E Acevedo, E Ciusani, J A Angulo, F A Wollheim, and M Sandberg-Wollheim
Tumour necrosis factor microsatellites and HLA-DRB1*, HLA-DQA1*, and HLA-DQB1* alleles in Peruvian patients with rheumatoid arthritis
Ann Rheum Dis, August 1, 2001; 60(8): 791 - 795.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
J Vinasco, A Fraile, A Nieto, Y Beraun, E Pareja, L Mataran, and J Martín
Analysis of LMP and TAP polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in rheumatoid arthritis
Ann Rheum Dis, January 1, 1998; 57(1): 33 - 37.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.