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© 1995 British Society for Rheumatology

research-article

RHEUMATOID FACTOR ASSOCIATED WITH A SECRETORY COMPONENT IN RHEUMATOID ARTHRITIS

C. JORGENSEN*,{dagger},, M. MOYNIER{dagger}, C. BOLOGNA*,{dagger}, P. YOUINOU{ddagger} and J. SANY*,{dagger}

*Department of Immuno-Rheumatology, Centre Gui-de-Chauliac 34295 Montpellier Cedex 5
{dagger}INSERM U291 99 rue Puech-Villa, Zolad, 34197 Montpellier Cedex
{ddagger}Laboratory of Immunology, Brest University Medical School Hospital F-29609 Brest Cedex, France

Correspondence to: Correspondence to: C. Jorgensen, Department of Immuno-Rheumatology, Centre Gui-de-Chauliac, 34295 Montpellier Cedex 5, France.

The authors' objective was to study the serum secretory immunoglobulin A (S-IgA) concentration and the presence of rheumatoid factor (RF) complexed with a secretory component (SC) in rheumatoid arthritis (RA). Sixty-three RA patients were studied. There were 49 healthy subjects in the control group. The S-IgA concentration and the presence of IgA isotype RF were determined by ELISA in the serum. The presence of SC complexed to RF (SC–RF) was studied by a sandwich-type enzyme-linked immunosorbent assay with an antibody against the SC used to capture S-immunoglobulin, and associated anti-globulin activity was revealed with a peroxidase-conjugated human IgG Fc fragment. We observed a significant increase in S-IgA in RA (mean 76.8 µg/ml ± 152.9 S.D.), as compared to controls (mean 13.6 µg/ml± 11.9 S.D.) (P <0.01). Forty-one per cent of RA patients presented a S-IgA concentration above the upper threshold, but we did not observe any association with disease activity. S-IgA concentration was correlated with the presence of IgA-RF. Twenty-seven RA patients had a positive SC–RF versus one in the control group (P<0.01). The presence of SC–RF was associated with an increased S-IgA concentration (P <0.0001), and the presence of RF-IgA (P <0.002). However, no association with disease activity was noted. Our study showed that serum S-IgA was increased in RA, and that part of the RF were complexed with SC. These results suggest contribution of mucosal lymphocytes in the pathogenesis of RA.

KEY WORDS: Secretory immunoglobulin, Rheumatoid factor, Rheumatoid arthritis, Mucosa-associated lymphoid tissue


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