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© 1995 British Society for Rheumatology

research-article

THE EFFECT OF LIPOSOMALLY CONJUGATED METHOTREXATE UPON MEDIATOR RELEASE FROM HUMAN PERIPHERAL BLOOD MONOCYTES

A. S. WILLIAMS, Y. L. PUNN, N. AMOS, A. M. COOPER and B. D. WILLIAMS

Rheumatology Research Laboratory, University of Wales College of Medicine Heath Park, Cardiff CF4 4XN

Correspondence to: Correspondence to: A. S. Williams.

The ability of methotrexate (MTX) and a liposomal preparation containing a lipophilic conjugate of methotrexate (MTX-LIPO) to modulate pro-inflammatory mediator release from lipopolysaccharide-stimulated human peripheral blood monocytes was investigated. At non-toxic concentrations MTX-LIPO (10 µg MTX per 250 µg lipid) was a potent inhibitor of both IL-1ß and TNF release resulting in 70.07 ± 2.3% and 59.19 ± 2.36% (mean ± S.E.M.) inhibition, respectively, whereas empty liposomes (E-LIPO; 250 µg lipid/well) of the same lipid composition and free MTX (up to 100 µg/well) had no effect on either mediator.

KEY WORDS: Tumour necrosis factor, Interleukin-1ß, Methotrexate, Liposome, Macrophage


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