© 1995 British Society for Rheumatology
research-article |
LEVELS OF CIRCULATING INTERCELLULAR ADHESION MOLECULE-1 AND -3 BUT NOT CIRCULATING ENDOTHELIAL LEUCOCYTE ADHESION MOLECULE ARE INCREASED IN PATIENTS WITH RHEUMATOID VASCULITIS
*Department of Rheumatology, University Hospital Leiden, The Netherlands
Diabetes Research Institute at the Heinrich Heine University Düsseldorf, Germany
Department of Clinical Research Unit on Rheumatology, Albert Ludwigs University Freiburg, Germany
Department of Medical Statistics, University Hospital Leiden, The Netherlands
¶Bender Medical Systems Vienna, Austria
Correspondence to:
Correspondence to: A. E. Voskuyl, University Hospital Leiden, Department of Rheumatology, Building I, C4-R, P.O. Box 9600, 2300 RC Leiden, The Netherlands.
The aim of this study was to investigate whether levels of circulating adhesion molecules reflect vascular inflammationin rheumatoid vasculitis (RV). Levels of circulating intercellular adhesion molecule-1 (cICAM-1), c-ICAM-3 and circulating endothelial leucocyte adhesion molecule (cE-selectin) were determined in 14 patients with RV and compared to 47 patients with rheumatoid arthritis (RA) and 100 healthy donors (HD). Enzyme-linked immunosorbent assays were used to quantify cICAM-1, cICAM-3 and cE-selectin. We found that in RV significantly (P<0.0001) elevated levels of cICAM-1 and cICAM3, butnot cE-selectin, were found when compared with RA patients. Levels > 2 S.D. above the mean level of HD were present for cICAM-1, cICAM-3 and cE-selectin in 57, 71 and 21%, respectively of patients with RV and 2, 21 and 44%, respectively of the RA patients. Increased levels of both cICAM-1 and cICAM-3 were found in 43% of the RV patients and in none of the RA patients. Comparison of the serum levels of patients studied in an active and inactive phase of RV revealed significantly lower levels of cICAM-3 levels in the inactive phase. In conclusion we find that determination of cICAM-1 and cICAM-3 may be useful as a marker of vascular inflammation in patients with RV.
KEY WORDS: Adhesion molecules, Rheumatoid arthritis, Vasculitis, cICAM-1, cICAM-3, cE-selectin
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