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© 1995 British Society for Rheumatology

research-article

ANTIBODIES TO KLESBSIELLA PNEUMONIAE, ESCHERICHIA COLI AND PROTEUS MIRABILIS IN THE SERA OF ANKYLOSING SPONDYLITIS PATIENTS WITH /WITHOUT IRITIS AND ENTHESITIS

O. MÄKI-IKOLA*, K. LETHINEN{dagger}, P. TOIVANEN{ddagger} and K. GRANFORS*,{ddagger},

*National Public Health Institute, Department in Turku Turku
{dagger}Rhemuatism Foundation Hospital Heinola
{ddagger}Department of Medical Microbiology, Turku University Turku, Finland

Correspondence to: Correspondence to: K. Granfors, National Public Health Institute, Department in Turku, Kiinamyllnaktu 13,SF-20520 Turku, Finland

IgM, IgG and IgA class serum antibodies against the whole Klebsiella pneumoniae, Escherichia coli and Proteus mirabilis bacteria,as well as against K. pneumoniae and E. coli lipopolysaccharides (LPSs) were studied earlier in the sera of 98 patients with ankylosing spondylitis (AS) and in 102 healthy blood denors by enzyme immunoassay. In this study the patients were divided into groups according to the clinical picture, i.e. presence or absence of iritis and enthesitis. The previous major finding of increased IgA class antibody levelsagainst the whole K. pneumoniae bacteria in AS patients when compared to the healthy controls was not specifically associated with any single patient group in the present study. However, the patients with iritis had higher levels of IgA class antibodies to LPS of K. pneumoniae and E. coli when compared to the patients without iritis. In addition, the patients without enthesitis had higher level of IgG class antibodies against whole K. pneumoniae bacteria compared to the patients with enthesitis. The increased IgA classantibody levels against K. pneumoniae and E. coli LPS in AS patients with iritis may reflect an inflammatory process in the gut area. Furthermore, there were certain other differences in the immunological parameters between the AS patients with and without intis or enthesitis and the possibility that they reflect different mechanisms involved in the disease processes cannot be excluded.

KEY WORDS: Ankylosing spondylitis, Antibodies, Klebsiella pneumoniae, Escherichia coli, Porteus mirabillis, Enzyme-linked immunoassay, Iritis, Enthesitis


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