Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by COMBE, B.
Right arrow Articles by BRESSOLLE, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by COMBE, B.
Right arrow Articles by BRESSOLLE, F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1995 British Society for Rheumatology

research-article

TOTAL AND FREE METHOTREXATE PHARMACOKINETICS, WITH AND WITHOUT PIROXICAM, IN RHEUMATOID ARTHRITIS PATIENTS

B. COMBE*,, L. EDNO{dagger}, P. LAFFORGUE{ddagger}, C. BOLOGNA§, J.-C. BERNARD*, P. ACQUAVIVA{ddagger}, J. SANY§ and F. BRESSOLLE{dagger}

*Department of Rheumatology, Caremeau Hospital Nimes
{dagger}Department of Pharmacokinetics, Caremeau Hospital Nimes
{ddagger}Department of Rheumatology, La Timone Hospital Marseille
§Department of Immuno-Rheumatology, Gui-de-Chauliac Hospital and INSERM U291 Montpellier, France

Correspondence to: Correspondence to: B. Combe, Service de Rhumatologie, Hôpital Carémeau, 30900 Nîmes, France.

The pharmacokinetic profile of total and free methotrexate (MTX) and the effect of piroxicam on MTX pharmacokinetics was studied in 20 rheumatoid arthritis patients receiving a stable dosage of MTX (10 mg/week). Plasma protein bindingranged from 25 to 55%. To describe the variations with time of the unbound fractions a mathematical characterization relationship between the total and free MTX was used. Total and free MTX were correlated with the sigmoid maximum effect model. The slope factor (gamma) was proportional to the number of binding sites. The free fraction for a given patient canbe evaluated from this relationship. Total clearance of MTX was not statistically different with piroxicam (8.01/h for total MTX, 13.71/h for free MTX) vs without piroxicam. Likewise, there were no significant difference in (tmax, area under the plasma concentration vs time curve, distribution and elimination half-lives, mean resonance time, and volumes of distribution. Although the highest observed total MTX concentration was significantly lower with piroxicam, there were no significant pharmacokinetic interactions between low-dose MTX and piroxicam.

KEY WORDS: Methotrexate pharmacokinetics, Piroxicam, Rheumatoid arthritis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Clin. Cancer Res.Home page
C. J. Sweeney, C. H. Takimoto, J. E. Latz, S. D. Baker, D. J. Murry, J. H. Krull, K. Fife, L. Battiato, A. Cleverly, A. K. Chaudhary, et al.
Two Drug Interaction Studies Evaluating the Pharmacokinetics and Toxicity of Pemetrexed When Coadministered with Aspirin or Ibuprofen in Patients with Advanced Cancer
Clin. Cancer Res., January 15, 2006; 12(2): 536 - 542.
[Abstract] [Full Text] [PDF]

Home page
 The Annals of PharmacotherapyHome page
S. N Hartmann, C. M Rordorf, S. Milosavljev, J. M Branson, G. H Chales, R. R Juvin, P. Lafforgue, J. M. Le Parc, C. G Tavernier, and O. C Meyer
Lumiracoxib Does Not Affect Methotrexate Pharmacokinetics in Rheumatoid Arthritis Patients
Ann. Pharmacother., October 1, 2004; 38(10): 1582 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
F Bressolle, C Bologna, J M Kinowski, J Sany, and B Combe
Effects of moderate renal insufficiency on pharmacokinetics of methotrexate in rheumatoid arthritis patients
Ann Rheum Dis, February 1, 1998; 57(2): 110 - 113.
[Abstract] [Full Text]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.