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© 1995 British Society for Rheumatology

research-article

INCREASE OF ACTIVATED FACTOR VIIA AND HAEMOSTATIC MOLECULAR MARKERS IN JUVENILE CHRONIC ARTHRITIS

Y. INAMO*, S. PEMBERTON, E. G. D. TUDDENHAM and P. WOO

Sections of Molecular Rheumatology and Haemostasis Research Group, MRC Clinical Research Centre, Northwick Park Hospital Watford Road, Harrow HA 13UJ
*Department of Paediatrics, Nihon University School of Medicine Itabashi-ku, Tokyo 173, Japan

Correspondence to: Correspondence to: P. Woo, UCLMS, The Windeyer Building, 46 Cleveland Street, London WIP 6DB.

Activated factor VIIa (FVIIa), von Willebrand factor antigen (vWF:Ag), D-dimer and thombin-antithrombin III complex (TAT) were measured to monitor coagulation status in patients with juvenile chronic arthritis (JCA). Subjects included 14 patients with systemic JCA, 16 with pauciarticular JCA and 16 with polyarticular JCA without disseminated intravascular coagulopathy, thrombosis or liver dysfunction. All types of JCA showed an increase of FVIIa, D-dimer and TAT, indicating enhanced activation of coagulation. In systemic JCA only there was also characteristically an elevation of vWF:Ag. We conclude that all types of JCA constitute a state of subclinical hypercoagulopathy caused by tissue damage and that additionally systemic JCA involves a prothrombotic state associated with or precipitated by vasculitis.

KEY WORDS: Factor VIIa, Juvenile chronic arthritis


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