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© 1995 British Society for Rheumatology

research-article

LACK OF TEMPORAL ASSOCIATION OF IRIDOCYCLITIS WITH IgG REACTIVITIES TO CORE HISTONES AND NUCLEOSOME SUBPARTICLES IN PAUCIARTICULAR JUVENILE CHRONIC ARTHRITIS

M. MASSA*, F. DE BENEDETTI, P. PIGNATTI, S. ALBANI, M. MONESTIER{dagger} and A. MARTINI

Clinica Pediatrica, Università degli Studi di Pavia, IRCCS Policlinico San Matteo 27100 Pavia, Italy
{dagger}Center for Molecular Medicine and Immunology Newark, NJ, USA

Correspondence to: Correspondence to: A. Martini, Clinica Pediatrica, Università di Pavia, IRCCS Policlinico San Matteo, P. le Golgi 2, 27100 Pavia, Italy.

This study aimed to measure IgG reactivities to DNA-free nucleosome subparticles (H2AH2B, H3H4) and nucleosome subparticles (H2AH2B–DNA, H3H4–DNA) and to evaluate the temporal relation of these reactivities, as well as those to single core histones, with iridocyclitis (IC) in patients with antinuclear antibody positive (ANA +) pauciarticular juvenile chronic arthritis (JCA). Reactivities to nuclear substrates were determined by enzymatic immunoassays in 120 sera from 45 children with ANA + pauciarticular JCA. Significantly elevated IgG levels to H3 and H4, to DNA-free nucleosome subparticles, and to the nucleosome subparticle H3H4–DNA were present in patients with ANA + pauciarticular JCA; no evidence of recognition of conformational epitopes was found. In both horizontal and follow-up studies, no relation between the reactivities studied and the development, presence, or history of IC was found. Our results show the absence of a relation of antibodies to histone molecules or to nucleosome subparticles with IC in patients with ANA+ pauciarticular JCA.

KEY WORDS: Juvenile chronic arthritis, Antinuclear antibodies, Iridocyclitis

*Present address: Laboratorio Biotecnologie e Tecnologie Biomediche, IRCCS Policlinico San Matteo, 27100 Pavia, Italy.


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