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© 1995 British Society for Rheumatology

research-article

INCREASED LEVELS OF ANTIBODIES TO HEAT SHOCK PROTEINS WITH INCREASING AGE IN MRL/MP-LPR/LPR MICE

G. FAULDS*, S. CONROY*, M. MADAIO{dagger}, D. ISENBERG{ddagger} and D. LATCHMAN*,

*Medical Molecular Biology Unit, Department of Molecular Pathology 46 Cleveland St, London W1P 6DP
{dagger}University of Pennsylvania School of Medicine 422 Curie Boulevard, Philadelphia, PA 19104-6144, USA
{ddagger}Bloomsbury Rheumatology Unit, Department of Medicine, University College London Medical School London

Correspondence to: Correspondence to: D. Latchman, Medical Molecular Biology Unit, Department of Molecular Pathology, 46 Cleveland Street, London W1P 6DP.

Approximately 30% of human patients with systemic lupus erythematosus (SLE) develop IgG autoantibodies to the highly conserved 90 kDa heat shock protein (hsp90). The development of anti-hsp90 antibodies is shown here to be paralleled in the Mrl/lpr mouse, which is an acknowledged model for SLE, but not in control BALB/c mice (P = 0.005). The generation of these antibodies appears to be closely linked to the onset of disease and titres of these antibodies increase with age, but there is no correlation with well-established clinical parameters of disease. Antibodies to hsp70 and hsp65 are also observed in the Mrl/lpr model; these antibodies appear to be unrelated to the pathogenesis of the disease.

KEY WORDS: Heat shock proteins, Autoantibodies, Mrl/lpr mouse, SLE


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