© 1996 British Society for Rheumatology
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ONCOPROTEIN EXPRESSION IN HUMAN SYNOVIAL TISSUE: AN IMMUNOHISTOCHEMICAL STUDY OF DIFFERENT TYPES OF ARTHRITIS
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*Turku Immunology Centre FIN-20520 Turku, Finland
Department of Medical Microbiology FIN-20520 Turku, Finland
Department of Pathology FIN-20520 Turku, Finland
Department of Medical Biochemistry and Centre for Biotechnology FIN-20520 Turku, Finland
¶Department of Surgery FIN-20520 Turku, Finland
||Department of Medicine, Turku University FIN-20520 Turku, Finland
Correspondence to:
Correspondence to: A. Roivainen, Department of Medical Microbiology, Turku University, FIN-20520 Turku, Finland
Based on the fact that synovial lining cells have some properties of transformed-appearing cells, we have examined the expression of Myc, Myb, Fos, Jun and Ras oncoproteins in synovial tissues from patients with different types of arthritis. Formalin-fixed and paraffin-embedded sections of synovial tissue from 12 patients with rheumatoid arthritis (RA), 14 with reactive arthritis (ReA), nine with other seronegative arthritis (OSA), seven with bacterial arthritis (BA), eight with probable bacterial arthritis (PBA) and eight with osteoarthritis (OA) were studied using the immunoperoxidase staining technique. The oncoproteins studied were expressed both in the synovial lining layer and in the sublining layer, consisting of lymphocytes, other inflammatory cells and blood vessels. Among the six disease entities, RA and OA appeared to be the most distinct, whereas the results obtained for ReA and OSA, and on the other hand for BA and PBA, closely resembled each other. The expression of Myc, Myb, Fos and Jun was significantly correlated both to the degree of synovial hypercellularity and the synovial lymphocytic infiltration. For Ras, such a correlation could not be seen. We conclude that we find no evidence of a cell lineage-specific or a disease-specific abnormality of proto-oncogene products in RA, and the expression of these oncoproteins is consistent with inflammation rather than with any primary abnormality of cell growth.
KEY WORDS: Oncoproteins, Rheumatoid arthritis, Reactive arthritis, Osteoarthritis, Synovial tissue
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