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© 1996 British Society for Rheumatology

research-article

ASSESSMENT OF URINARY HYDROXYPYRIDINIUM CROSS-LINKS MEASUREMENT IN OSTEOARTHRITIS

M. P. HELLIO LE GRAVERAND, A. M. TRON, M. ICHOU*, M. C. DALLARD, M. RICHARD*, D. UEBELHART{dagger} and E. VIGNON

Pavilion F place d'Arsonval, 69437 Lyon Cedex 03, France
*Biochemistry Laboratory, Claude Bernard University, Edouard Herriot Hospital place d'Arsonval, 69437 Lyon Cedex 03, France
{dagger}University Hospital of Geneva, Switzerland and Rush Presbyterian, St Luke'sMedical Center Chicago, IL, USA

Correspondence to: Correspondence to: E. Vignon, Claude Bernard University, Edouard Herriot Hospital, Pavilion F, place d'Arsonval, 69437 Lyon Cedex 03, France.

The aim of this study is to re-evaluate urinary collagen cross-links, previously proposed as markers of osteoarthritis (OA). The urinary excretion of collagen cross-links, pyridinoline (PYD) and deoxypyridinoline (DPD), was measured using high-performance liquid chromatography (HPLC) in 114 patients with OA, 19 patients with rheumatoid arthritis (RA) and 40 healthy subjects. An increase in PYD and DPD, expressed per millimole of creatinine, was confirmed in RA. However, PYD and DPD in patients with hip OA, knee OA and polyOA were similar, and did not differ from controls. In patients with radiographic end-stage OA, PYD and DPD were significantly higher than in patients with an early OA, but not significantly higher than in controls. The PYD/DPD ratio did not vary with the OA stage. Thus, urinary collagen cross-links are not elevated in OA, but could reflect bone sclerosis and/or erosion in late OA.

KEY WORDS: Pyridinium cross-links, Osteoarthritis, Rheumatoid arthritis


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