© 1996 British Society for Rheumatology
research-article |
INCREASED NAILFOLD CAPILLARY DIMENSIONS IN PRIMARY RAYNAUD'S PHENOMENON AND SYSTEMIC SCLEROSIS
University of Manchester, Rheumatic Diseases Centre, Hope Hospital Salford M6 8HD
Correspondence to:
Correspondence to: M. Bukhari.
The aim of the study was to measure nailfold capillary dimensions and capillary density in patients with primary Raynaud's phenomenon (PRP) and systemic sclerosis (SSc) compared to control subjects. Ten controls, nine patients with PRP and 10 patients with SSc were studied. All dimensions other than distance between limbs were significantly increased in both the PRP and SSc groups compared to controls (P < 0.01), with the SSc group showing the most marked increases (SSc vs PRP, P < 0.05 for all dimensions). Capillary density was significantly reduced in the SSc group compared to controls (P = 0.004). These results suggest that structural vascular changes occur in PRP as well as in SSc, and that PRP may, therefore, not be entirely benign.
KEY WORDS: Scleroderma, Systemic sclerosis, Primary Raynaud's phenomenon, Nailfold capillary microscopy, Capillary dimensions
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. P Cooke and J. M Marshall Mechanisms of Raynaud's disease Vascular Medicine, November 1, 2005; 10(4): 293 - 307. [Abstract] [PDF]
|
|
|
|
 |
|
 A. L. Herrick Pathogenesis of Raynaud's phenomenon Rheumatology, May 1, 2005; 44(5): 587 - 596. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Murray, A. L. Herrick, and T. A. King Laser Doppler imaging: a developing technique for application in the rheumatic diseases Rheumatology, October 1, 2004; 43(10): 1210 - 1218. [Full Text] [PDF]
|
|
|
|
|
|
M. E. Anderson, T. L. Moore, S. Hollis, M. I. V. Jayson, T. A. King, and A. L. Herrick Digital vascular response to topical glyceryl trinitrate, as measured by laser Doppler imaging, in primary Raynaud's phenomenon and systemic sclerosis Rheumatology, March 1, 2002; 41(3): 324 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. S. Seitz, H. J. Kline, and M. B. McIlroy Quantitative Assessment of Peripheral Arterial Obstruction in Raynaud's Phenomenon: Development of a Predictive Model of Obstructive Arterial Cross-Sectional Area and Validation with a Doppler Blood Flow Study Angiology, December 1, 2000; 51(12): 985 - 998. [Abstract] [PDF]
|
|
|
|
|
|
M. Keberle, H.-P. Tony, R. Jahns, M. Hau, R. Haerten, and M. Jenett Assessment of microvascular changes in Raynaud's phenomenon and connective tissue disease using colour Doppler ultrasound Rheumatology, November 1, 2000; 39(11): 1206 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bukhari, S. Hollis, T. Moore, M. I. V. Jayson, and A. L. Herrick Quantitation of microcirculatory abnormalities in patients with primary Raynaud's phenomenon and systemic sclerosis by video capillaroscopy Rheumatology, May 1, 2000; 39(5): 506 - 512. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L Herrick and S. Clark Quantifying digital vascular disease in patients with primary Raynaud's phenomenon and systemic sclerosis Ann Rheum Dis, February 1, 1998; 57(2): 70 - 78. [Full Text]
|
|