© 1996 British Society for Rheumatology
brief-report |
COAGULATION FACTOR V GENE MUTATION INCREASES THE RISK OF VENOUS THROMBOSIS IN BEHÇET'S DISEASE
,
*Division of Rheumatology, Department of Internal Medicine, Istanbul Medical School Istanbul
Department of Genetics, Institute for Experimental Medicine (DETAM), Istanbul University Istanbul
Department of Molecular Biology and Genetics, Faculty of Science, Bilkent University Ankara, Turkey
Correspondence to:
Correspondence to: A. G
l, Zuhuratbaba Mah. Trkis Cad. No: 14/8, Bakirk
y, Istanbul 34740, Turkey
We investigated the prevalence of the coagulation factor V gene G1691A mutation in 64 patients with Behçet's disease (BD) and in 107 apparently healthy individuals. The mutation was present in the heterozygous state in 37.5% of the patients with a history of deep vein thrombosis (12/32) and in 9.4% of the patients without any thrombotic event (3/32). Eleven healthy individuals were also heterozygous for the mutation (10.3%). The prevalence of the mutation in BD patients with and without thrombosis was significantly different (P = 0.0079). We conclude that the factor V gene mutation may play a major role in the development of venous thrombosis in BD.
KEY WORDS: Behcet's disease, Factor V gene mutation, Activated protein C resistance, Deep vein thrombosis, Vasculitis
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  L.M. Al-Otaibi, S.R. Porter, and T.W.J. Poate Behcet's Disease: A Review Journal of Dental Research, March 1, 2005; 84(3): 209 - 222. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M Leiba, U Seligsohn, Y Sidi, D Harats, B A Sela, J H Griffin, A Livneh, N Rosenberg, I Gelernter, H Gur, et al. Thrombophilic factors are not the leading cause of thrombosis in Behcet's disease Ann Rheum Dis, November 1, 2004; 63(11): 1445 - 1449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D H Verity, G R Wallace, R W Vaughan, and M R Stanford Behcet's disease: from Hippocrates to the third millennium Br J Ophthalmol, September 1, 2003; 87(9): 1175 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y Chen, M R Stanford, G R Wallace, R W Vaughan, E Kondeatis, and F Fortune Factor V Leiden mutation does not correlate with retinal vascular occlusion in white patients with Behcet's disease Br J Ophthalmol, August 1, 2003; 87(8): 1048 - 1049. [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Oztuirk, Z. Ozbalkan, A. M. Onat, I. Ertenli, S. Kiraz, K. Aytemir, K. Ureten, G. Abali, M. Calguineri, S. Kirazli, et al. Decreased Protein Z Concentrations Complicating the Hypercoagulable State of Behqet's Disease Clinical and Applied Thrombosis/Hemostasis, July 1, 2003; 9(3): 259 - 263. [Abstract] [PDF]
|
|
|
|
 |
|
 Z Morcos Recurrent orogenital ulcers with papilloedema and headaches Postgrad. Med. J., May 1, 2002; 78(919): 317 - 317. [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. J. Ames, A. Steuer, A. Pap, and A. M. Denman Thrombosis in Behcet's disease: a retrospective survey from a single UK centre Rheumatology, June 1, 2001; 40(6): 652 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Aksu, N. Turgan, F. Oksel, G. Keser, D. Ozmen, G. Kitapcioglu, G. Gumusdis, O. Bayindir, and E. Doganavsargil Hyperhomocysteinaemia in Behcet's disease Rheumatology, June 1, 2001; 40(6): 687 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gul, A. B. Aslantas, T. Tekinay, M. Konice, and T. Ozcelik Procoagulant mutations and venous thrombosis in Behcet's disease Rheumatology, December 1, 1999; 38(12): 1298 - 1299. [Full Text] [PDF]
|
|