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© 1996 British Society for Rheumatology

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MONOCYTE ACTIVITY IN BEHÇET'S DISEASE

S. SAHlN, (ÖZGÜN), R. LAWRENCE, H. DIRESKENELI, V. HAMURYUDAN*, H. YAZICI* and T. AKOGLU

Department of Immunology, Marmara Medical School Istanbul, Turkey
*Department of Rheumatology, Cerrahpasa Medical School Istanbul, Turkey

Correspondence to: Correspondence to: T. Akogiu, Marmara Tip Fakultesi Hastanesi, Altunizade, Istanbul, Turkey.

Monocytes obtained from patients with Behçet's disease (BD) were examined for differentiation markers (expression of CD14 and antigens reacting with monoclonal antibodies 25F9 and G16/1) and for expression of selected adhesion molecules. There was significantly raised expression of the CD14 molecule, and increased staining with 25F9 and G16/1 antibodies in monocytes obtained from patients with BD. A monocyte activation marker, soluble CD 14, was also found to be raised in patients' serum compared with normal serum (8.1 ± 9.2 vs 1.4 ± 0.7 µg/ml). Furthermore, BD patients' monocyte culture supernatants caused significantly increased adhesion of normal neutrophils to endothelial cell monolayers in vitro. All these findings show that BD patients' monocytes are active in vivo and produce a number of pro-inflammatory cytokines which may play a role in the chronic inflammation found in these patients.

KEY WORDS: Monocyte, Behçet's disease, Adhesion molecules


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