REVERSIBLE OVULATORY FAILURE ASSOCIATED WITH THE DEVELOPMENT OF LUTEINIZED UNRUPTURED FOLLICLES IN WOMEN WITH INFLAMMATORY ARTHRITIS TAKING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

doi:10.1093/rheumatology/35.5.458

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REVERSIBLE OVULATORY FAILURE ASSOCIATED WITH THE DEVELOPMENT OF LUTEINIZED UNRUPTURED FOLLICLES IN WOMEN WITH INFLAMMATORY ARTHRITIS TAKING NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

G. SMITH, R. ROBERTS^*, C. HALL^* and G. NUKI

^*Centre for Reproductive Biology, University of Edinburgh Edinburgh EH3 9EW
Rheumatic Diseases Unit, Western General Hospital Edinburgh EH4 2XU

Correspondence to: Correspondence to: G. Nuki, Rheumatic Diseases Unit, University of Edinburgh, Western Gerneral Hospital, Crewe Road South, Edinburgh EH4 2XU.

The case histories of three young women with ankylosing spondylitis,rheumatoid arthritis and a seronegative inflammatory polyarthritisundergoing investigations for infertility are presented. Ineach, non-steroidal anti-inflammatory drug (NSAID) therapy wasassociated with the recurrent development of luteinized unrupturedovarian follicles and normal ovulation following drug withdrawal.It is suggested that NSAID therapy may be an important and frequentlyoverlooked cause of anovulation and infertility.

KEY WORDS: Arthritis, Non-steroidal anti-inflammatory agents, Infertility, Ovulation, Luteal phase

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