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© 1996 British Society for Rheumatology

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THE VALUE OF ISOTYPE DETERMINATION OF SERUM ANTIBODIES AGAINST CHLAMYDIA FOR THE DIAGNOSIS OF CHLAMYDIA REACTIVE ARTHRITIS

S. BAS, T. CUNNINGHAM, T. K. KVIEN*, A. GIENNÅS*, K. MELBY{dagger} and T. L. VISCHER

{dagger}Department of Microbiology, Ullevàl University Hospital Oslo, Norway
*Oslo City Department of Rheumatology, Norwegian Lutheran Hospital Oslo
Division of Rheumatology, University Hospital Geneva, Switzerland

Correspondence to: Correspondence to: S. Bas, Research Laboratory, Division of Rheumatology, University Hospital, 1211 Geneva 14, Switzerland.

In clinical rheumatology, the diagnosis of Chlamydia reactive arthritis is difficult because an incomplete form of the disease can closely resemble an undifferentiated seronegative mono/oligoarthritis. We investigated whether measuring specific isotypes of anti-Chlamydia antibodies in serum can improve the diagnosis, by comparing such antibody concentrations in the serum of patients with well-defined disease, i.e. Chlamydia trachomatis sexually acquired reactive arthritis (CT-SARA), with other arthritides. Antibody levels were determined by enzyme-linked immunosorbent assay (ELISA). When considering two different isotypes and their combination, the best sensitivity (63%) was obtained for IgM and/or IgA results with a specificity of 81%. The patients with CT-SARA and SARA had the highest levels of antibodies of all isotypes tested. It is concluded that, in our experimental conditions, only very high values of specific isotypes could indicate a diagnosis of Chlamydia reactive arthritis.

KEY WORDS: Sexually acquired reactive arthritis, Chlamydia, Antibodies, Enzyme-linked immunoassay


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