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© 1996 British Society for Rheumatology

other

PHOSPHATTDYL SERINE-DEPENDENT ANTIPROTHROMBIN ANTIBODY IS EXCLUSIVE TO PATIENTS WITH LUPUS ANTICOAGULANT

J. MATSUDA, N. SAITOH, M. GOTOH, K. KAWASUGI, K. GOHCHI and M. TSUKAMOTO

Department of Medicine, Teikyo University School of Medicine 11-1, Kaga 2-Chome, Itabashi-Ku, Tokyo 173, Japan

We conducted this study to determine whether antiprothrombin antibody (aPT) [to prothrombin (PT) alone or PT/phosphatidyl serine (PS) complex] actually existed in patients with lupus anticoagulant (LA) and/or anticardiolipin antibody (aCL). aPT to PT alone was positive in 2/7 LA-positive (29%) and 3/7 LA/aCL-positive (43%) patients. aPT to PT/PS complex was positive in 4/7 LA-positive (57%) and 4/7 LA/aCL-positive (57%) patients in the presence of Ca2+. However, none of the aCL-positive patients without LA or the LA/aCL-negative patients were positive for aPT and aPT/PS. Thus, we confirmed the existence of aPT and aPT/PS specifically among LA-positive patients. However, the clinicopathological significance of aPT and aPT/PS in this clinical setting is yet to be clarified.

KEY WORDS: Anticardiolipin antibody, Antiprothrombin antibody, Lupus anticoagulant, Thrombosis


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[Abstract] [Full Text] [PDF]


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