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© 1996 British Society for Rheumatology

other

ANTIBODIES TO FOUR GRAM-NEGATIVE BACTERIA IN RHEUMATOID ARTHRITIS WHICH SHARE SEQUENCES WITH THE RHEUMATOID ARTHRITIS SUSCEPTIBILITY MOTIF

H. TIWANA*, C. WILSON*, P. CUNNINGHAM{dagger}, A. BINDER{ddagger} and A. EBRINGER*,§,

*Division of life Sciences, Infection and Immunity Group, King's College London W8 7AH
{dagger}Department of Computing, King's College London W8 7AH
{ddagger}Departments of Rheumatology, Lister Hospital Stevenage
§Department of Rheumatology, UCL School of Medicine, Middlesex Hospital London

Correspondence to: Correspondence to: A. Ebringer, Infection and Immunity Group, Division of Life Sciences, King's College, Campden Hill Road, London W8 7 AH.

The bacteria Proteus, Serratia, Escherichia and Pseudomonas possess sequences resembling the rheumatoid arthritis susceptibility sequence EQRRAA, but antibodies were elevated only to Proteus in 66 RA patients (P<0.001) when compared to 61 active ankylosing spondylitis patients and 60 controls.

KEY WORDS: Rheumatoid arthritis, Proteus mirabilis, Gram-negative bacteria


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