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© 1996 British Society for Rheumatology


case-report

TERTIARY HYPERPARATHYROIDISM AFTER LONG-TERM PHOSPHATE SUPPLEMENTATION IN ADULT-ONSET HYPOPHOSPHATAEMIC OSTEOMALACIA

J. NARVnumeroEZ, J. RODRIGUEZ-MORENO, C. MORAGUES, E. CAMPOY, T. CLAVAGUERA and D. ROIG-ESCOFET

Department of Rheumatology, Hospital Principes de Esparia, Ciudad Sanitaria y Universitaria de Bellvitge, Hospitalet de Liobregat Barcelona, Spain

Correspondence to: Correspondence to: J. Narvnumeroez, Department of Rheumatology, Hospital Prindpcs de Espafia, Ciudad Sanitaria y Universitaria de Bellvitge, C/ Feixa Llarga S/N, 080907, Hospitalet de Uobregat, Barcelona, Spain.

We report the development of tertiary hyperparathyroidism in a patient with a sporadic form of adult-onset hypophosphataemic osteomalacia who had been treated with vitamin D or calcitriol and large doses of phosphate. This observation suggests that even with concomitant vitamin D or calcitriol therapy, long-term oral phosphate supplementation may lead to the development of hypercaicaemic hyperparathyroidism. Caution is recommended when relatively large doses of phosphate are used to treat hypophosphataemic osteomalacia of diverse causes.

KEY WORDS: Hypophosphataemic osteomalacia, Long-term phosphate therapy, Tertiary hyperparathyroidism


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