© 1996 British Society for Rheumatology
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INCREASED BACTERIAL UREASE ACTIVITY IN FAECES IN JUVENILE CHRONIC ARTHRITIS: EVIDENCE OF ALTERED INTESTINAL MICROFLORA?
Medical School, University of Tampere and Department of Paediatrics, Tampere University Hospital Finland
*Department of Clinical Nutrition, University of Kuopio Finland
Department of Biochemistry and Food Chemistry, University of Turku Finland
Correspondence to:
Correspondence to: M. Malin, Medical School, University of Tampere, PO Box 607, 33101 Tampere, Finland.
The intestinal microflora was indirectly evaluated in juvenile chronic arthritis (JCA) by analysing enzyme activities-urease, ß-glucosidase and ß-glucuronidase—in faeces. In 18 out of 26 JCA patients, the illness had been diagnosed during the past year. The control group was composed of eight age-matched control patients and 18 family members of JCA patients (3–36 yr). The mean [95% confidence interval (CI)] urease activity, but not the activities of ß-glucosidase and ß-glucuronidase, in faeces from the JCA group differed from that in the control group: 32.3 (26.6–38.1) nmol/min/mg protein vs 24.0 (16.8–31.6), P = 0.07. The difference was more marked in a comparison of JCA patients with family members (P = 0.03). In a subgroup of subjects, the effect of 10 days oral bacteriotherapy with Lactobacillus GG on faecal enzyme activities was then investigated (n = 8 JCA patients, n = 8 control patients). This short-term oral bacteriotherapy reduced the increased urease activity in faeces of JCA patients. Keeping in mind the small number of subjects, it may be inferred from the present results that the increased urease activity in JCA is specific for the disease, suggesting altered intestinal microflora in JCA.
KEY WORDS: Juvenile chronic arthritis, Intestinal microflora, Urease, ß-glucosidase, ß-glucuronidase
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