Skip Navigation

This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Demsar, F.
Right arrow Articles by Brasch, R. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Demsar, F.
Right arrow Articles by Brasch, R. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1996 British Society for Rheumatology

Mapping Abnormal Synovial Vascular Permeability in Temporomandibular Joint Arthritis in the Rabbit Using MRI

F. Demsar*,{dagger}, C. F. van Dijke*, B. A. Kirk{ddagger}, S. Kapila{ddagger}, C. G. Peterfy*, T. P. L. Roberts*, D. M. Shames*, S. Tomazic{dagger}, J. Mann* and R. C. Brasch*

* Department of Radiology, University of California San Francisco, CA, USA
{dagger} Jozef Stefan Institute, University of Ljubljana Ljubljana, Slovenia
{ddagger} Department of Growth and Development, University of California San Francisco, CA, USA

Correspondence to: Correspondence to: Franci Demsar, Jozef Stefan Institute, Jamova 39,61000 Ljubljana, Slovenia


  Abstract

An automated method for two-dimensional spatial depiction (mapping) of quantitative physiological tissue characteristics derived from contrast-enhanced MRI was applied to a model of inflammatory disease represented by antigen-induced arthritis of the temporomandibular joint in the rabbit. Specifically, an established two-compartment kinetic model of unidirectional mass transport was implemented on a pixel-by-pixel basis to generate maps of tissue permeability surface area product (PS) and fractional blood volume (BV) based on dynamic MRI intensity data after administration of albumin-(Gd-DTPA)30, a prototype macromolecular contrast medium designed for blood pool enhancement. Maps of PS and BV in a disease model of induced arthritis clearly depicted zones of increased permeability (up to ~200 µl/cc/h—compared to 25 µl/cc/h in normal tissues).

KEY WORDS: Arthritis, Macromolecular contrast media, MRI, Permeability


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.