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© 1996 British Society for Rheumatology

Prognostic Value of Contrast Enhanced Gd-DTPA MRI for Development of Bone Erosive Changes in Rheumatoid Arthritis

V. Jevtic*, I. Watt{dagger}, B. Rozman{ddagger}, M. Presetnik{ddagger}, D. Logar{ddagger}, S. Praprotnik{ddagger}, M. Tomsic{ddagger}, A. Sipek{ddagger}, M. Kos-Golja{ddagger}, A. Sepe§, O. Jarh§, F. Demsar§, P. Musikic and G. Campion

* Radiology Institute, University Medical Centre Ljubljana Slovenia
{dagger} Department of Clinical Radiology, Bristol Royal Infirmary Bristol
{ddagger} Department of Rheumatology, University Medical Centre Ljubljana Slovenia
§ Institute Jozef Stefan Ljubljana, Slovenia
Clinical Research Department Amgen Synergen B V, The Hague, The Netherlands

Correspondence to: Correspondence to: V. Jevtic, Radiology Institute, University Medical Centre Ljubljana, Slovenia


  Abstract

Conventional radiograms have been used to quantitate the progression of rheumatoid arthritis, mainly through the assessment of bone erosions, but this approach has many limitations. It has been suggested that an advantage of contrast-enhanced Gd-DTPA MRI over radiography may be its prognostic value due to its ability to show the natural history of active destructive to inactive fibrous pannus. The aim of this study was to evaluate the possible prognostic value of MRI for future development of bone erosive changes in small hand joints in patients with RA. The results of the study confirm that in joints in which inflammatory active pannus is shown by contrast-enhanced MRI, progression of bone-destructive changes can be expected

KEY WORDS: Magnetic resonance imaging, Progression of bone erosions, Rheumatoid arthritis


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