The British Journal of Rheumatology, Vol 36, 113-116, Copyright © 1997 by British Society for Rheumatology
M Teixido, J Font, JC Reverter, R Cervera, D Tassies, M Ingelmo, G Escolar and A Ordinas
We studied anti-beta 2-glycoprotein I antibodies (a beta 2GPI) in
autoimmune disease patients to evaluate their relationship to clinical
findings. Seventy-nine systemic lupus erythematosus (SLE) patients [44 with
antiphospholipid antibodies (aPL)], 21 with primary antiphospholipid
syndrome (APS), eight asymptomatic individuals with aPL and 60 controls
were studied. Sixteen SLE patients (14 with aPL and two without aPL) and
six with primary APS had a beta 2GPI. A significant relationship was found
between a beta 2GPI and aPL (P < 0.01). In SLE, a significant
correlation was found between previous thrombosis or thrombocytopenia and a
beta 2GPI or a beta 2GPI + aPL, but not between fetal losses and a beta
2GPI. These data suggest that a beta 2GPI may be useful in the study of
APS.
ORIGINAL PAPERS
Anti-beta 2-glycoprotein I antibodies: a useful marker for the antiphospholipid syndrome
Systemic Autoimmune Diseases Unit, Hospital Clinic, Barcelona, Spain.
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