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The British Journal of Rheumatology, Vol 36, 124-125, Copyright © 1997 by British Society for Rheumatology

ORIGINAL PAPERS

Leucocytoclastic vasculitis associated with hepatitis C virus antibodies

R Manna, L Todaro, M Latteri, G Gambassi, G Massi, MR Grillo, A Romito, S Caputo and GB Gasbarrini
Department of Internal Medicine, Catholic University of Sacred Heart, Rome, Italy.

The actiopathogenesis of leucocytoclastic vasculitis is still unknown, but recently hepatitis C virus (HCV) has been suggested as trigger of autoimmunity. We report a case of a 26-yr-old patient with purpura due to leucocytoclastic vasculitis associated with hepatitis C virus infection. Laboratory findings showed AST, ALT, gamma GT within normal limits, positive antibodies to HCV (IIF and Riba II) and polymerase chain reaction for HCV RNA. Anti-nuclear antibodies, IgG and IgM anti- cardiolipin antibodies, anti-platelet antibodies and anti-neutrophil cytoplasmic antibodies with perinuclear pattern were also present. A skin biopsy specimen of a purpuric lesion showed leucocytoclastic vasculitis with small vessel thrombosis and perivascular deposition of IgM and fibrinogen on immunofluorescence study. This case shows a role of HCV in leucocytoclastic vasculitis; it is possible that this HCV can induce autoimmunity independently of cryoglobulins and liver involvement.
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