The British Journal of Rheumatology, Vol 36, 32-37, Copyright © 1997 by British Society for Rheumatology
I Gunnarsson, J Ronnelid, YH Huang, S Rogberg, B Nilsson, I Lundberg and L Klareskog
The aim of this study was to compare ongoing production of anti-C1q
antibodies (anti-C1q) in peripheral blood with serum anti-C1q levels in
patients with systemic lupus erythematosus (SLE), especially in patients
with nephritis. Using the ELISPOT technique for the detection of IgG and
IgA anti-C1q production, 21 patients with active SLE were investigated.
ELISAs for IgG and IgA anti-C1q were compared with the ELISPOT results. Six
of the patients were found to have proliferative nephritis (WHO grade
III/IV) confirmed by renal biopsy. High numbers of IgG anti-C1q
spot-forming cells (SFC), defined as > 20/10(5) plated peripheral blood
mononuclear cells (PBMC), were exclusively observed in patients with
proliferative nephritis (P < 0.0001). Serum levels of IgG anti-C1q were
significantly increased in patients with proliferative nephritis (P =
0.039). High ongoing IgG anti-C1q production was observed in all patients
with proliferative nephritis, which may be a contributory factor in the
pathogenesis of this disorder. The detection of IgG anti-C1q production may
be valuable in the clinical investigation of patients with suspected SLE
nephritis.
ORIGINAL PAPERS
Association between ongoing anti-C1q antibody production in peripheral blood and proliferative nephritis in patients with active systemic lupus erythematosus
Department of Rheumatology, Karolinska Hospital, Stockholm Sweden.
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