The British Journal of Rheumatology, Vol 36, 50-53, Copyright © 1997 by British Society for Rheumatology
AG MacDonald, G Birkinshaw, B Durham, RC Bucknall and WD Fraser
To investigate bone turnover in patients with seronegative
spondylarthropathy, a bone formation marker, type 1 procollagen carboxy-
terminal propeptide (P1CP), and resorption markers, the pyridinium
cross-links of collagen [urinary free (f) PYR and DPYR], were measured. The
median f-PYR, f-DPYR and P1CP (+/-interquartile range) were 15.8 (6.00)
nmol/mmol creatinine, 3.8 (2.2) nmol/mmol creatinine and 101.5 (38)
micrograms/1, respectively. There was a positive correlation between
resorption markers and acute-phase reactants such as C-reactive protein (r
= 0.42 for PYR, r = 0.42 for DPYR, P < 0.05), and a negative correlation
observed between P1CP and the erythrocyte sedimentation rate (r = -0.64, P
< 0.05). In the subgroup of patients with an elevated CRP concentration,
the concentration of PYR and DPYR was significantly increased (f-PYR 25.7
vs 15.8 and f-DPYR 6.6 vs 3.8, P < 0.01 for f-PYR, P < 0.05 for
f-DPYR). This study suggests than an elevation in acute-phase response in
patients with seronegative spondylarthropathy is associated with increased
concentration of bone resorption markers with a tendency for reduction in
bone formation markers. This may represent uncoupling of bone formation and
resorption, leading to bone loss in such patients.
ORIGINAL PAPERS
Biochemical markers of bone turnover in seronegative spondylarthropathy: relationship to disease activity
Department of Rheumatology, Royal Liverpool University Hospital.
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