The British Journal of Rheumatology, Vol 36, 1270-1275, Copyright © 1997 by British Society for Rheumatology
H Ihn, S Sato, M Fujimoto, K Kikuchi, T Kadono, K Tamaki and K Takehara
We measured serum levels of circulating intercellular adhesion molecule- 1
(cICAM-1) in patients with systemic sclerosis (SSc) and normal controls.
The levels of cICAM-1 were determined by sandwich enzyme- linked
immunosorbent assay in sera from 88 patients with SSc and in 20 healthy
controls. In addition, these levels were examined in the supernatants of
cultured peripheral blood mononuclear cells (PBMC) and dermal fibroblasts
from 10 patients with SSc and 10 healthy control subjects. Serum levels of
cICAM-1 were significantly higher in patients with SSc than in healthy
controls. Serum cICAM-1 levels were significantly higher in patients with
diffuse cutaneous SSc (dcSSc) than in patients with limited cutaneous SSc
(lcSSc). These serum levels were correlated with the presence of
contracture of phalanges, pulmonary fibrosis, joint involvement and
increased erythrocyte sedimentation rate. The release of cICAM-1 was
significantly increased in the supernatants of cultured PBMC from patients
with SSc. Moreover, inflammatory cytokines (interferon-gamma, interleukin-1
and tumor necrosis factor-alpha) enhanced the release of cICAM-1 in vitro
in SSc cells. These findings suggest that cICAM-1 may be involved in immune
reactions in this disease.
ORIGINAL PAPERS
Circulating intercellular adhesion molecule-1 in the sera of patients with systemic sclerosis: enhancement by inflammatory cytokines
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
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