The British Journal of Rheumatology, Vol 36, 1276-1282, Copyright © 1997 by British Society for Rheumatology
M Aringer, WB Graninger, JS Smolen, HP Kiener, CW Steiner, F Trautinger and R Knobler
We investigated the effects of photopheresis in systemic sclerosis by
analysing its influence on lymphocytes with regard to apoptosis and
expression of bcl-2 and fas. Peripheral blood lymphocytes isolated
immediately before and 24 h after photopheresis were investigated for
apoptosis, bcl-2 and fas expression by fluorocytometry, and compared to
controls. In addition, leucocytes from systemic sclerosis patients taken
directly from the photopheresis system were tested for apoptosis after 24 h
in culture. fas expression was similar in controls and patients with
systemic sclerosis just before photopheresis, but increased 24 h after
photopheresis, mainly due to an increase of CD4+CD95+ cells. bcl-2 was
overexpressed in scleroderma peripheral lymphocytes, but not influenced by
photopheresis. As compared to healthy controls, the percentage of apoptotic
cells 24 h after photopheresis was high in cultured lymphocytes, but not ex
vivo. The significant increase in fas on peripheral lymphocytes observed in
this study may be a major operative mechanism of photopheresis in addition
to (and possibly related to) the induction of apoptosis.
ORIGINAL PAPERS
Photopheresis treatment enhances CD95 (fas) expression in circulating lymphocytes of patients with systemic sclerosis and induces apoptosis
Department of Rheumatology, University of Vienna, Austria.
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