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The British Journal of Rheumatology, Vol 36, 174-177, Copyright © 1997 by British Society for Rheumatology

ORIGINAL PAPERS

Post-partum flare in MRL-lpr/lpr mice is associated with a parallel increase of N-acetylglucosamine on serum IgG

A Bond, LG Ratkay, JD Waterfield and FC Hay
Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London.

Our objective was to investigate IgG glycosylation and disease activity post partum in the MRL-lpr/lpr mouse. Disease activity was monitored using bimalleolar ankle swelling. Levels of galactose and N- acetylglucosamine (GlcNAc) on IgG isolated from serum were measured using biotinylated lectins. Our results show that disease severity increased post partum. This post-partum flare correlated significantly with an increase in IgG GlcNAc expression. The disease severity increased post partum in the MRL-lpr/lpr mouse model similar to the changes seen in rheumatoid arthritis (RA).
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L. G. Ratkay, J. Weinberg, and J. D. Waterfield
The effect of lactation in the post-partum arthritis of MRL-lpr/fasmice
Rheumatology, June 1, 2000; 39(6): 646 - 651.
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