The British Journal of Rheumatology, Vol 36, 229-233, Copyright © 1997 by British Society for Rheumatology
DA Isenberg, M Garton, MW Reichlin and M Reichlin
The aim was to determine whether the autoantibody profile in Black female
lupus patients is associated with clinical subsets, fluctuates over time
and/or reflects disease activity. A clinical comparison with Caucasian and
Asian patients matched for age of onset and disease duration was also
undertaken. Up to seven serial bleeds from Black female lupus patients who
had been followed up for periods of 3.15 yr were tested for antibodies to
Ro/SSA, La SSB. Sm, RNP and ribosomal P using ELISA research assays.
Significant differences in both clinical and serological profiles between
the ethnic groups were found. Varying aspects of disease activity were
linked to anti-DNA (renal, cardiovascular, global score), anti-ribosomal P
(musculoskeletal, haematology) and anti-Sm (general) antibodies. There are
differences in clinical and serological profiles amongst systemic lupus
erythematosus patients of different ethnic origin. However, using the BILAG
system, relatively few antibodies were found to reflect disease activity
accurately in serial measurements.
ORIGINAL PAPERS
Long-term follow-up of autoantibody profiles in black female lupus patients and clinical comparison with Caucasian and Asian patients
Centre for Rheumatology/Bloomsbury Rheumatology Unit. Department of Medicine, University College London.
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