The British Journal of Rheumatology, Vol 36, 234-238, Copyright © 1997 by British Society for Rheumatology
S Marsal, C Falga, CP Simeon, M Vilardell and JA Bosch
The effects of pregnancy on the course of Behcet's disease (BD), and vice
versa, are unknown and little has been reported. We have studied three
groups of women: (1) group A included 61 pregnancies in 23 women with BD,
25 pregnancies took place in 10 patients already diagnosed (group 1A) and
36 pregnancies occurred in 13 patients before disease diagnosis (group 2A);
(2) group B included 30 females with 83 pregnancies affected by recurrent
oral ulcers (ROU); (3) group C included 20 healthy women with 61
pregnancies. We investigated the effects of BD on pregnancy and fetal
outcome, and the influence of gestation on the course of BD. A
questionnaire was used in which specific information about each pregnancy,
labour and puerperium was collected. We looked for medical confirmation in
all cases where any pathology had been identified. No significant
differences were found in the incidence of pregnancy complications between
groups. The incidence of perinatal death was also similar and neither
congenital abnormalities nor neonatal BD were observed. Only two patients
observed a flare of the disease and in two cases the diagnosis of BD was
made during the pregnancy. In our series, the outcome of pregnancy was
generally good in BD patients, disease manifestations were not consistently
worsened and fetal outcome was excellent. The first case of Budd-Chiari
syndrome during the puerperium in a BD patient is reported.
ORIGINAL PAPERS
Behcet's disease and pregnancy relationship study
Internal Medicine Service, Hospital General i Universitari Vall d' Hebron, Barcelona, Spain.
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