The British Journal of Rheumatology, Vol 36, 239-243, Copyright © 1997 by British Society for Rheumatology
CP Denton, JB Cailes, GD Phillips, AU Wells, CM Black and RM Bois
Pulmonary hypertension (PHT) is an important complication of systemic
sclerosis (SSc). Echocardiography can be used to detect PHT and, with
Doppler echocardiography, the pulmonary arterial systolic pressure (PASP)
can often be estimated. We have undertaken a study to compare
echocardiographic assessment with right heart catheterization (RHC) in 33
SSc patients in whom clinical assessment [including ECG, chest X- ray, lung
function tests and high-resolution computed tomography (HRCT) had raised
strong suspicion of PHT. The mean (S.D.) interval between echocardiography
and RHC was 1.8 (2.3) months. Twenty-one patients (64%) had PHT (PASP >
or = 30 mmHg) on RHC, and echocardiography correctly identified 19 of these
(sensitivity 90%). Of the 12 patients without PHT on RHC, nine were
correctly identified by echocardiography (specificity 75%). The five
incorrectly classified patients all had PASP in the borderline
normal/abnormal range. The presence of tricuspid regurgitation allowed
Doppler measurement of PASP in 20 patients (61%) and this correlated
significantly with RHC values (r = 0.83, P < 0.001). We conclude that
echocardiography is a reliable method for detecting PHT and it may be
particularly useful for the early detection and monitoring of this
potentially fatal complication in SSc.
ORIGINAL PAPERS
Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis
Academic Rheumatology and Connective Tissue Diseases Unit, Royal Free Hospital Medical School, London.
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|
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