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The British Journal of Rheumatology, Vol 36, 289-291, Copyright © 1997 by British Society for Rheumatology

ORIGINAL PAPERS

Anti-RNP antibody in a child with undifferentiated carcinoma and no evidence of mixed connective tissue disease

HE Foster, PN Malleson, RE Petty and DA Cabral
Department of Rheumatology, Freeman Hospital, Newcastle upon, Tyne.

We describe a young girl who presented with musculoskeletal symptoms and who was found to have high titres of antinuclear antibody with anti- RNP antibody. She was initially suspected of having mixed connective tissue disease, but ultimately was found to have metastatic undifferentiated carcinoma with an unknown primary site. This is a very uncommon malignancy of childhood and an association with anti-RNP antibody has, to our knowledge, not been described. The clinical significance of this finding is discussed.
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